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KMID : 0615720110280040019
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Jouranl of Korean Acupuncture and Moxibustion society
2011 Volume.28 No. 4 p.19 ~ p.35
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The Effects of Perpendicular Needling Laogong () on the Improvement of Cerebral Hemodynamics in Rats
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Heo Jin
Kim Jung-Ho
Kim Young-Il
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Abstract
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Objectives: This study was designed to investigate the effects of acupuncturing used perpendicular needling method determine the mechanism of action of acupuncturing by measuring the changes of regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP) in normal rats.
Methods: This study also investigated the effects of acupuncturing on the change of rCBF in cerebral ischemic rats, and revealed the mechanism of its action. In addition, the effects of acupuncturing on focal ischemic brain injury was studied in cerebral ischemic rats.
Results: 1. Acupuncturing significantly increase rCBF but decreased MABP in normal rats. 2. Acupuncturing increased of rCBF was significantly inhibited by pretreatment with indomethacin (1mg/kg, i.p.), an inhibitor of cyclooxygenase in normal rats. 3. Acupuncturing increased of rCBF was significantly inhibited by pretreatment methylene blue (10 /kg, i.p.), an inhibitor of guanylate cyclase in normal rats. 4. Acupuncturing was significantly improved the rCBF than control group increased unstable in cerebral ischemic rats. 5. Acupuncturing was not significantly improved the rCBF than control group by pretreatment with indomethacin (1mg/kg, i.p.), an inhibitor of cyclooxygenase in cerebral ischemic rats. 6. Acupuncturing was significantly increased the rCBF than control group by pretreatment methylene blue (/kg, i.p.), an inhibitor of guanylate cyclase in cerebral ischemic rats.
Conclusions: In conclusion, our study suggested that acupuncturing can increase rCBF in normal state, and improve stability of rCBF in ischemic state. In addition, we suggested that mechanisms related with acupuncturing was involved in the guanylate cyclase pathway.
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KEYWORD
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Laogong (), cerebral hemodynamics, regional cerebral blood flow (rCBF), mean arterial blood pressure (MABP)
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